Beekeeping makes significant contributions to both the agricultural economy and crop production through pollination. Protecting the health of honey bees is of critical importance. It is evaluated that in an environment without bees, crop production may decrease by 47%. Many factors in the beekeeping sector negatively affect honey production. Among these reasons, microorganism-induced diseases as well as organism-induced diseases and hazards are at the forefront. Various strategies are used to protect the health of honey bees. However, pests and diseases are still not prevented. The most important of these are chemicals due to their widespread use. These products jeopardize both bee health and bee product quality. Methods using biological materials, which are more environmentally friendly than chemical control, should be preferred. Among these methods, biological control method stands out. As a result, the use of biological products as an alternative is critical for both the health of the organisms and the elimination of residues. The use of microorganisms and their products as biological control agents in the protection of bee health will be an important step in this regard.