Strand-based engineered wood products (EWPs) have been widely employed in construction since their emergence in the 1970s. The use of strand-based EWPs can significantly increase the yield of forest resources by utilizing submarginal logs and branches. In this chapter, the strand-based EWPs, including oriented strand board (OSB), laminated strand lumber (LSL), and oriented strand lumber (OSL), are discussed in terms of their fabrication, properties, and uses in construction. Specifically, the manufacturing requirements for elements (i.e., strands), such as dimension, density, and moisture content, are introduced. The major manufacturing processes, such as selection of adhesives, pressing parameters, and thickness control, are also discussed. In addition, the engineering properties and uses of these EWPs are illustrated. Furthermore, some innovative applications of these products, such as hybrid cross-laminated timber, are presented in this chapter.