Obesity, with growing prevalence around the world, is a disease and a major risk factor for noncommunicable diseases and death. Lifestyle medicine integrates modern lifestyle practices with scientific evidence-based medicine in order to lower risk factors for chronic diseases and to support therapy if the disease is already present. Considering adiposity-based chronic disease conceptual model and new abdominal obesity classification, this article intends to describe healthy lifestyle pillars that must be considered in obesity prevention and treatment. Right nutrition, regular physical activity, optimal sleep, moderation in alcohol consumption, absence of smoking, and mindfulness should be considered in the effort to prevent and treat obesity. Doctor-patient partnership, patient empowerment, and doctor as a role model will complete the basic principle of lifestyle medicine.