Entrepreneurship is a crucial element for each country that aims to be competitive and developed within knowledge-based world economy. In “Green Paper on Entrepreneurship in Europe” (2003) European Commission defines entrepreneurship as “the mindset and process to create and develop economic activity by blending risk-taking, creativity and/or innovation with sound management, within a new or an existing organisation”. Extant literature on entrepreneurship concludes by the thesis that entrepreneurs can be made (Gorman et al, 1997, Henry et al, 2005). Taking the words of Drucker (1985) “It’s not magic, it’s not mysterious, and it has nothing to do with the genes. It’s a discipline. And, like any discipline, it can be learned”. In this sense, entrepreneurs can be taught and schools have an important role in this process. Following Kuratko (2005), an” entrepreneurial perspective” can be developed in individuals. Nowadays Higher Education Institutions have an important role in the improvement of entrepreneurship, being part of an entrepreneurial ecosystem with business and government. The market labor faced many changes in last year’s, the unemployment rates increased in Europe and the possibility of creation a firm comes as an important way to add value to economy and to create jobs. In this environment, universities and colleges must provide entrepreneurship education, develop and adapt competencies, skills, disseminate knowledge, technology and increase economic development as well as help students to create new firms and provide the adequate set of training to manage them across their life cycle. Considering the question How to improve entrepreneurship in higher education? this chapter aims to present an entrepreneurship ecosystem developed in Setubal Polytechnic Institute (SPI) Portugal, and discuss some results in an early stage of implementation as well as propose future directions and discuss some barriers faced in the implementation of the model. The literature is particular intense in the analysis of the effectiveness of a particular course or initiative and less focused in an integrated approach of how can Higher Education Institutions promote entrepreneurship. We propose to study entrepreneurship education as 1