The study was conducted to investigate the effect of teacher’s qualification and instructional material on students’ performance in Mathematics in Jos metropolis. Three (3) research questions and three (3) hypotheses were formulated for the study. A sample size of one hundred (100) students was selected for the study through simple random sampling technique. The research design used for the study was a descriptive survey design. A Questionnaire was used as instruments for data collection. Descriptive statistics of mean and standard deviation were used to answer the research questions and inferential statistics of chi-test was used to test the research hypotheses. findings of the study revealed that teacher qualification has significant effect on students’ performance in Mathematics in Jos Metropolis. The findings of the study showed that teacher’ years of teaching experience has significant effect students’ performance in Mathematics in Jos Metropolis. The study also revealed that the availability and teachers’ ability to use instructional materials has significant effects on students’ performance in Mathematics in Jos metropolis. It was recommended that the government and employers of teachers should recruit qualified teachers to teach Mathematics at the senior secondary school level. It was also recommended that Mathematics teachers with long term teaching experience should be assigned to teach the subject.