In the development of intelligent power grid system construction in China, the scale of urban power grid construction is getting larger and larger. How to realize the integration of substation operation and maintenance has become the main issue explored by scholars in the field. Because there are still many problems in the operation and maintenance management of intelligent substation, such as ignoring safety measures, rising work risk factor, lack of high-quality talents, etc., the construction of smart grid should explore how to change from the traditional management mode to the integrated operation and maintenance mode. After understanding the basic concept of integrated operation and maintenance mode of intelligent substation, this paper mainly explores the system construction and application effect of integrated operation and maintenance management of intelligent substation according to the basic objectives and common problems of practical management, and finally proposes effective countermeasures for specific problems.