Healthcare maintains a high priority on pain management, and research to develop safer and more potent analgesics is ongoing. Natural goods, especially plants, have recently attracted renewed interest as potential sources of analgesic medications. In this study, various techniques are used to measure pain. The rich source of analgesics found in medicinal plants includes Moringa oleifera, Aloe barbadensis, Curcuma longa, Eugenia caryophyllata, Adhatoda vasica, Mentha piperita, Ocimum sanctum, Zingiber officinale, Lavandula angustifolia, Epilobium angustifolium, Dialium guineense, Sida acuta, Stylosanthes fruticose, Bougainvilla spectabilis, Ficus glomerata, Polyalithia longifolia, Calotropis gigantea, Tinospora cordifolia, Ageratina glabrata, Mangifera indica, Peperomia pellucida, Jatropha gossypifolia, Leonotis leonurus, Mimosa rubicaulis, Cussonia paniculate, Biebersteinia multifida, Alternanthera sessislis, Mentha arvensis, Oroxylum indicum, Tamarindus indica, Cucurbita maxima, Cucumis sativus, Emblica officinalis, Angiopteris evecta, Parastrephia lephidophylla, Peperomia pellucida, Scoparia dulcis, Ficus racemose, Eremostachys laciniata, Phlogacanthus thyrsiflorus, Kigelia pinnata, Molineria capitulate, Manihot esculenta, Ficus religiosa, Dalbergia sissoo, Grangea maderaspatana, Nothospondias staudtii, Rhodiola rosea, Juniperus communis, Erythrina variegate etc. The results reported in this review paper represent scientific knowledge that may be applied in the future to isolate potentially active molecules from some of these medicinal plants.