Abstract Traditional medicaments, chiefly obtained from plants have played a vital role in sustaining disease free human existence on this planet. In spite of overwhelming influence of modern science and tremendous advances made in the production of synthetic drugs, traditional medicaments designed as herbal drugs in different places in the literature have retained their place in the therapy. In this context the folk medicine Ficus hispida was studied for its nephroprotective activity. The nephroprotective effect of fruits of Ficus hispida (Moraceae) were investigated by acute toxicity studies, estimation of biochemical parameters and in vitro antioxidant studies. In our investigation methanolic extract showed significant nephroprotective activity than nephrocuration on cispaltin induced nephrotoxicity.