Based on the theoretical analysis, with first-hand data collection and using multiple regression models, this study explored the relationship between openness, conscientiousness and extraversion, stressor and psychological stress response and figured out interactive effect of openness, conscientiousness and extraversion, and stressor on psychological stress response. We draw on the following conclusions: (1) the interaction term of stressor (family) and openness can negatively predict psychological stress response; (2) the interaction term of stressor (social) and conscientiousness can positively predict psychological stress response; (3) the interaction term of stressor (social) and extraversion can negatively predict psychological stress response.