Atherosclerosis consists the leading cause of cardiovascular diseases. Over the last years, medicinal plants are considered as efficient agents in the prevention and adjuvant therapy of atherosclerosis. Mountain tea (Sideritis plants) is used as traditional remedy against common cold and gastrointestinal disorders. Its beneficial properties are attributed to its rich bioactive constituents. Polyphenols exhibit a broad range of pharmacological activities such as antioxidant, anti-inflammatory and anti-atherosclerotic effects. The present review summarizes and discusses the potential of mountain tea as an anti-atherogenic agent based on its bioactive chemical compounds and their reported pharmacological activities.