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Communications for Statistical Applications and Methods
Article . 2012 . Peer-reviewed
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Communications for Statistical Applications and Methods
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https://dx.doi.org/10.5351/cks...
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Maximum Tolerated Dose Estimation Applied Biased Coin Design in a Phase I Clinical Trial

descriptionPublicationkeyboard_double_arrow_right Article 30 Nov 2012 English Publisher:The Korean Statistical SocietyJournal:Communications for Statistical Applications and Methods, volume 19, pages 877-884 (issn: 2287-7843, Copyright policy )
Authors: Yu Rim Kim; Dongjae Kim;

doi: 10.5351/ckss.2012.19.6.877

Maximum Tolerated Dose Estimation Applied Biased Coin Design in a Phase I Clinical Trial

Abstract

Phase I trials determine the maximum tolerated dose(MTD) and the recommended dose(RD) for subsequent Phase II trials. In this paper, a MTD estimation method applied to a biased coin design is proposed for Phase I Clinical Trials. The suggested MTD estimation method is compared to the SM3 method and the NM method (Lee and Kim, 2012) using a Monte Carlo simulation study.

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
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