The article is devoted to the problem of regulating the number of rodents at food industry, public catering facilities, etc., where the vital activity of micromammals carries the risk of spreading infectious diseases, leads to contamination or damage of products and communication networks, causing significant economic losses. The article considers deratization as a component of the pest control system—control of harmful organisms, according to the global concept of food safety (HACCP). The main regulatory acts of Ukraine on this issue are presented. The scheme of organisation of rodent control on the example of one of the enterprises is considered in detail, which includes the construction of a three-level system of protection against rodents, which allows monitoring their population. This method of rodent control takes into account the requirements of the current legislation of Ukraine and European standards.