Most viticultural regions in the world annually sustain spring frost injury-associated yield loss. Researchers have developed sprayable products to prevent spring frost injury by delaying budbreak. The goal of this research was to evaluate the efficacy of novel products, including Amigo oil,® ProTone,® and FrostShield,® to delay budbreak and the effect of these products on vegetative and reproductive growth in grapevines. The early budbreaking cultivars La Crescent and Marquette were used in field experiments in 2018 and 2019 and in a growth chamber experiment in 2019. Treatments included a control (no spray), 10% (v/v) Amigo oil, 500 mg/L S-ABA ProTone, and FrostShield. In field experiments, FrostShield consistently delayed the budbreak of both cultivars for four to six days, while the other two products showed a very limited effect. In addition, FrostShield did not affect cultivars’ vegetative or reproductive growth. In the growth chamber experiment, FrostShield delayed the budbreak of two cultivars for more than two weeks, while the effect of the other two products was inconsistent between cultivars. Our results indicate that FrostShield outperformed Amigo oil and ProTone by consistently delaying budbreak without negatively affecting vegetative or reproductive growth, suggesting that FrostShield might be an effective product to prevent spring frost injury.