Always prone to introspection and self-criticism, academic planners have been confessing recently that what occurs in the halls of academe may be unresponsive and irrelevant to the real life of planners. If the discipline of planning is tangential to the profession of planning, what role can regional science be expected to play? Rather than tackle the entire relationship between two expansive disciplines, I will to focus on three changes in the profession of planning that have occurred over the past 12 years and to look at the ways in which regional science has and might respond to these changes.