Grape yield regulation is a method used to improve grape quality parameters. Experiments were carried out in 2021 on the grapevine (Vitis vinifera L.) wine varieties 'Feteasca regala' and 'Sauvignon blanc', focusing on the effect of two different methods of grape yield regulation on its selected parameters and must sugar content. The first method used was cluster thinning, leaving one bunch on the shoot. The next method used was cluster tipping when we removed the terminal part of each bunch. Yield reduction was carried out in the period between pea-sized berry phenophase (BBCH 75) and bunch closure phenophase (BBCH 77). The operations were carried out manually. Cluster thinning did not lead to a statistically significant difference in bunch weight compared to the control in any of the studied varieties. We observed a statistically significant (p <0.05) decrease in the average bunch weight in the variant cluster tipping. The 'Feteasca regala' hectare yield was 32.25% lower in the cluster thinning than the control. The hectare yield in the cluster thinning variant was reduced by 46.61% compared with the control. Cluster thinning variant of the Sauvignon blanc variety had a 19.13% lower yield than the control variant. The cluster tipping variant had a 29.03% lower yield than the control variant. In the case of the cluster thinning method, we observed a greater decrease in grape yield compared to the cluster tipping method. The obtained results indicate that cluster tipping method is preferable to the cluster thinning in terms of the profitability of grape production. The must sugar content was statistically significantly (p <0.05) increased in all the yield reduction variants. The variety 'Feteasca regala' had the highest sugar content of the must in the cluster thinning method, 19.42 kg/hL. The highest sugar content of 'Sauvignon blanc' was 21.33 kg/hL in the variant with cluster tipping. This shows that regulating the grape yield can improve the quality parameters of the grapes. On the other hand, it may lead to a decrease in yield per hectare below the break-even point. The justness and intensity of the method used must be carefully considered.