The current analysis describes the scope and trends in United States content from the Vaccine Sentimeter's results, while seeking to examine any possible links between media content, vaccine coverage, and reported vaccine adverse events in the country. The findings emphasize the importance of the Vaccine Sentimeter as a valid tool for public health agencies. This tool may allow them to track any loss of confidence in a variety of vaccines, at either the national or state level, at an early enough stage to allow effective policy implementation.