Objective: Colonic lipomas are uncommon tumors of the gastrointestinal tract. Most of these tumors are asymptomatic and usually detected incidentally during colonoscopy or laparotomy and do not require treatment. Large lipomas are usually symptomatic and may mimic clinic manifestations of colonic carcinoma. Here we studied seven cases of submucosal and intramuscular colonic lipomas to evaluate the clinical features, diagnosis and treatment of this disease.