The modern business enterprise resulted from the integration of mass production with mass distribution within a single business firm. The American meat-packing industry created the typical type of enterprise exemplified by the “Big Five” at the beginning of the 20th century. However, the dominant status of the “Big Five” has ceased today. The industry clearly represents the category of slight to negligible barriers to entry, and might be labeled as “low moderate” concentration. This paper focuses on the resolution process of “Big Five” business structure under long-term technological trends. Section II and III argue that differences in entrepreneurial response to the refrigeration age brought forth three types of business structure. Section IV raises and attempts to answer the question of the decline of the “Big Five.”