This paper presents LRB-based hybrid base isolation systems employing additional active/semiactive control devices for mitigating earthquake-induced vibration of a cable-stayed 29 bridge. Hybrid base isolation systems could improve the control performance compared with the passive type-base isolation system such as LRB-installed bridge system due to multiple control devices are operating. In this paper, the additional response reduction by the two typical additional control devices, such as active type hydraulic actuators controlled by LQG algorithm and semiactive-type magnetorheological dampers controlled by clipped-optimal algorithm, have been evaluated bypreliminarily investigating the slightly modified version of the ASCE phase I benchmark cable-stayed bridge problem (i.e., the installation of LRBs to the nominal cable-stayed bridge model of the problem). It shows from the numerical simulation results that all the LRB based hybrid seismic isolation systems considered are quite effective to mitigate the structural responses. In addition, the numerical results demonstrate that the LRB based hybrid seismic isolation systems employing MR dampers have the robustness to some degree of the stiffness uncertainty of in the structure, whereas the hybrid system employing hydraulic actuators does not. Therefore, the feasibility of the hybrid base isolation systems employing semiactive additional control devices could be more appropriate in realfor full-scale civil infrastructure applications is clearly verified due to their efficacy and robustness.