Signal transducer and activator of transcription 3 regulation by novel binding partners
Copyright policy )Signal transducer and activator of transcription 3 regulation by novel binding partners
Signal transducers and activators of transcription (STATs) mediate essential signals for various biological processes, including immune responses, hematopoiesis, and neurogenesis. STAT3, for example, is involved in the pathogenesis of various human diseases, including cancers, autoimmune and inflammatory disorders. STAT3 activation is therefore tightly regulated at multiple levels to prevent these pathological conditions. A number of proteins have been reported to associate with STAT3 and regulate its activity. These STAT3-interacting proteins function to modulate STAT3-mediated signaling at various steps and mediate the crosstalk of STAT3 with other cellular signaling pathways. This article reviews the roles of novel STAT3 binding partners such as DAXX, zipper-interacting protein kinase, Krüppel-associated box-associated protein 1, Y14, PDZ and LIM domain 2 and signal transducing adaptor protein-2, in the regulation of STAT3-mediated signaling.
- Hokkaido University Japan
- Hokkaido Bunkyo University Japan
- Osaka University Japan
- Hokkeido University Japan
Signal transducer and activator of transcription 3, PDZ and LIM domain 2, Signal transduction, Nuclear factor-κB, 464, Krüppel-associated box-associated protein 1, Y14, DAXX, Janus kinase/signal transducer and activator of transcription, Zipper-interacting protein kinase, Signal transducing adaptor protein-2
Signal transducer and activator of transcription 3, PDZ and LIM domain 2, Signal transduction, Nuclear factor-κB, 464, Krüppel-associated box-associated protein 1, Y14, DAXX, Janus kinase/signal transducer and activator of transcription, Zipper-interacting protein kinase, Signal transducing adaptor protein-2
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