Historically, research in entrepreneurship has largely ignored biological factors. However, recently researchers have begun to explore the ways in which human biology affects this phenomenon. This literature has been fragmented, scattered across various outlets, making it difficult for entrepreneurship scholars to aggregate the findings and develop a broad theoretical perspective to describe how biology relates to entrepreneurship (Nofal, Nicolaou, Symeonidou, & Shane, 2018).\ud \ud In this chapter, we provide a systematic review of the biological perspective in entrepreneurship. Specifically, we systematically review research linking the three biological strands of genetics, physiology, and neuroscience to entrepreneurship. We discuss the findings of this growing literature and how incorporating biology into the study of entrepreneurship can enhance our understanding of various entrepreneurial outcomes. We then discuss the mechanisms through which biology affects entrepreneurship. Finally, we conclude with directions for future research.\ud