This paper is the second step of our work. The first step presents a set of parametric studies performed on automotive radiators by designing different heat exchanger models. The analysis focuses on the cooling performance for automobile radiator by changing several dimensions of the radiator fin phase (P2.5, P2.4, P2.3, P2.2, and P2.1) as well as the importance of coolant flow lay-out on the radiator global performance [1]. The second step consists on the study of the vibration fatigue of the sample with the best heat dissipation performance we design (radiator P2.1). We use Hyper Mesh to proceed with the finite element model. Frequency response analysis is solved by using MSC. Nastran (MSC. MD. Nastran. v2010.1.3-MAGNiTUDE), fatigue durability ana-lysis by using MSC Fatigue. In this experiment, the frequency response of the unit load (the unit load is 1 g) is analyzed. Based on the analysis of the frequency response of the unit load, the fatigue life of the radiator is analyzed by the PSD (power spectral density) curve and the S-N curve. From our experiments results, we observe that the radiator we design meets the international requirements of fatigue vibration under automobile normal working condition.