An investigation into the optimal design of a substation grounding system for the transmission substation in Gaza City, Palestine has been carried out. A research into the most influential parameters on the effectiveness of the substation grid system has been performed and its results have been incorporated into the Gaza case study. Through modelling and simulating the power station in Gaza while considering some field data, an optimal substation grounding grid has been designed and has shown complete conformance to safety. It is thus considered that such a design will protect personnel in any area of the substation in addition to the installed machinery if the largest possible fault current was to traverse the earth.