A high efficiency LED(Light Emitting Diode) driver based on Buck converter, which could operate under a wide AC input voltage range(85V~265V) and drive a series of high power LEDs, is presented in this paper. The operation principles, power loss factors of the LED driver in this study are analyzed and discussed in detail and some effective ways to improve efficiency are proposed through system design considerations. To verify the feasibility, a laboratory prototype is also designed and tested for an LED lamp which consists of 16 LUMILEDS LEDs in series. Experimental results show that a high efficiency of 92% at I0=350mA can be achieved and the studied driver might be practical for driving high power LEDs. In the last, the overall efficiency over 90% is gained through some experiments under variable input and output voltages and verifies the validity of the designed driver.