In mineral processing engineering disciplines, flotation, as a primary beneficiation method, is performed on the basis of surface chemical properties of minerals and rocks. The surface chemistry of minerals and rocks can be artificially changed to achieve minerals flotation separation. Thus chemistry plays a very important role in mineral processing engineering disciplines. Analysis shows that inorganic chemistry, organic chemistry and physical chemistry are all required courses for undergraduate students majoring in mineral processing engineering. Analytical chemistry and further quantum chemistry for advanced talent training at the graduate education level are necessary. Chemistry lays the foundation for realizing resource use in efficiency, integration and cleanliness, and plays a significant role in wastewater recycling, zero discharge and environment protection. Emphasizing chemistry education and improving chemistry expertise are an important guarantee for environment protection and sustainable development of mineral resources exploitation and utilization.