In this study, we establish an approximate method which produces an approximate Hermite polynomial solution to a system of fractional order differential equations with variable coefficients. At collocation points, this method converts the mentioned system into a matrix equation which corresponds to a system of linear equations with unknown Hermite polynomial coefficients. Construction of the method on the aforementioned type of equations has been presented and tested on some numerical examples. Results related to the effectiveness and reliability of the method have been illustrated.