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Rotavirus genotypes in Malaysia and Universal rotavirus vaccination

Name: Rotavirus genotypes in Malaysia and Universal rotavirus vaccination
Keywords: Male, Rotavirus, Vaccination, Infant, Newborn, Malaysia, Rotavirus Vaccines, RJ Pediatrics, Infant, Models, Theoretical, Rotavirus Infections

descriptionPublicationkeyboard_double_arrow_right Article 16 Oct 2012 Malaysia English Publisher:Informa UK LimitedJournal:Human Vaccines & Immunotherapeutics, volume 8, pages 1,401-1,406 (issn: 2164-5515, eissn: 2164-554X,

Authors: Lee, Way Seah; Lim, B.T.Y.; Chai, P.F.; Kirkwood, C.D.; Lee, J.K.F.;

doi: 10.4161/hv.21577

pmid: 23022710

pmc: PMC3660759

Rotavirus genotypes in Malaysia and Universal rotavirus vaccination

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Abstract

Group A rotavirus (RV-A) genotypes isolated in Malaysia was studied to estimate the effectiveness of a universal RV-A vaccination in Malaysia. A simple mathematical model was used, with input from a two-year, two-center, prospective study on hospitalization of RV-A gastroenteritis (RVGE) in young children, published data on RV-A hospitalizations and genotypes, mortality on childhood GE and published genotype-specific efficacy data on two RV-A vaccines. Assuming a 95% vaccine coverage, the overall projected effectiveness was 75.7 to 88.1% for Rotateq and 78.7 to 90.6% for Rotarix® against RVGE-related hospitalizations. The projected annual reduction in RVGE-related deaths was 27 to 32 deaths (from 34 deaths) for Rotateq and 28 to 32 deaths annually for Rotarix. A universal RV-A vaccine is efficacious in reducing RVGE-related hospitalizations and mortality in Malaysia.

Country

Malaysia

Related Organizations

Universiti Malaysia Terengganu
Malaysia
University Malaya Medical Centre
Malaysia
University of Malaya
Malaysia
Murdoch Children's Research Institute
Australia
Hospital Sultanah Nur Zahirah
Malaysia

Keywords

Male, Rotavirus, Vaccination, Infant, Newborn, Malaysia, Rotavirus Vaccines, RJ Pediatrics, Infant, Models, Theoretical, Rotavirus Infections, Child, Preschool, Humans, Female

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