The positive cell response to the implant material is reflected by the capacity of cells to divide, which leads to the tissue regeneration and osseointegration. Technically pure titanium and its alloys are mostly used for implant manufacturing. These alloys have the adequate mechanical, physical and biological properties; nevertheless, the superior biocompatibility of bioceramics has been proven. With the arrival of new coating techniques, surface modification of materials used for implants has become a widely investigated issue.The paper studied properties of titanium nitride (TiN) and zirconium nitride (ZrN) coatings deposited by PVD (Physical Vapour Deposition). Coatings were applied to substrates of pure titanium, Ti6Al4V, Ti35Nb6Ta titanium alloys and CoCrMo dental alloy. Different treatments of substrate surfaces were used: polishing, etching and grit blasting. Cytocompatibility tests assessed the cell colonization and their adherence to substrates.Results showed that TiN layers deposited by PVD are suitable for coating all substrates studied. The polished samples and those with TiN coating exhibited a higher cell colonization. This coating technique meets the requirements for the biocompatibility of the implanted materials; furthermore, their colour range solves the issue of red aesthetics in oral implantology as the colour of these coatings prevents titanium from showing through the gingiva. This is one the most important criteria for the aesthetic success of implant therapy (Tab. 5, Ref. 18).