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Journal of Oral and Maxillofacial Pathology
Article . 2014 . Peer-reviewed
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Journal of Oral and Maxillofacial Pathology
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Enigmatic Morpho Insight: Mitosis At A Glance

Authors: Radhika M Bavle;

Enigmatic Morpho Insight: Mitosis At A Glance

Abstract

NEOPLASM is an abnormal and un-coordinated growth of tissue, which is categorized by WHO (World Health Organization) as benign tumors, in-situ tumors, malignant tumors, and neoplasms of uncertain or unknown behavior.[1] Cancer is a malignant tumor featuring abnormal cell growth and cellular division resulting in excessive cellular proliferation, with the potential to invade or spread to other parts of the body.[2,3] Dysplasia is linked to altered tissue architecture, with one of the reasons being excessive cellular proliferation, leading in all probability to malignant transformation if not treated.[4] The cell cycle, or cell-division cycle, is the series of events that take place in a cell leading to its division and duplication (replication) that produces two daughter cells.[5] Cell division occurs in defined stages, which together comprise the cell cycle [Figure 1]. There are two types of cell division: Meiosis and Mitosis. Figure 1 Cell cycle illustration with duration, regulation, and inhibitors MEIOSIS: Occurs during formation of the gametes, the number of chromosomes reduced to half in reproductive cell[6] MITOSIS: Mitosis is the process in which a eukaryotic cell nucleus splits in two, followed by division of the parent cell into two daughter cells.[6] CELL CYCLE: Divided into two major events,[5] Interphase- Cell increases in size and replicates its genetic material Mitosis G0 phase- A resting phase where the cell has stopped dividing[5] INTERPHASE: G1 phase- Cells increase in size in Gap 1. The G1 checkpoint control mechanism ensures that everything is ready for DNA synthesis[5] S phase- DNA replication occurs during this phase[5] G2 phase- During the gap between DNA synthesis and mitosis, the cell will continue to grow. The G2 checkpoint control mechanism ensures that everything is ready to enter the M (mitosis) phase and divide[5] MITOSIS is subdivided into PROPHASE- This is the first stage of mitosis. In this phase, chromosomes are distinctly seen and centrioles move apart. Nuclear membrane disappears[7] [Figure 2] Figure 2 (a) Photomicrograph (H&E stain, ×400) (b) hand drawn illustration showing prophase of mitosis with condensed nuclear chromatin METAPHASE- Chromosomes are lined up along the metaphase or equatorial plate[7] [Figure 3] Figure 3 (a) Photomicrograph (H&E stain, ×400) (b) hand drawn illustration showing metaphase in mitosis ANAPHASE- Sister chromatids separate and begin to migrate to opposite poles of the cell and a cleavage furrow begins to develop[7] [Figure 4] Figure 4 (a) Photomicrograph (H&E stain, ×400) (b) hand drawn illustration showing division of chromosomal material in anaphase of mitosis TELOPHASE- Terminal phase of mitosis and characterized by cytokinesis, reconstitution of nucleus and nuclear envelope, disappearance of mitotic spindle, and unwinding of chromosomes into chromatin.[7] [Figure 5] Figure 5 (a) Photomicrograph (H&E stain, ×400) (b) hand drawn illustration showing telophase in mitosis with complete division and formation of a new set of daughter cells

Keywords

Enigmatic Morpho Insight

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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
9
Average
Average
Average
Green
gold