This open file provides an inventory of thermokarst pond development between 1945 and 2005 in a study area that is representative of the southern North Slave region between Behchoko and Yellowknife, Northwest Territories. The primary purpose of this inventory is to approximate the location and size of thermokarst ponds in a study area representative of the region to assist in better understanding present and future permafrost conditions. Because construction of the GNWT Highway 3 in the mid-1960s utilized locally-available fine-grained materials sourced along the right-of-way, we examine potential thermokarst initiation at those sites and compare ponding adjacent to the highway with results for the region. The inventory and database were prepared to evaluate the dominant controls on the distribution of thermokarst in the region, and the potential influence that highway construction may have had on thermokarst development. The accompanying shapefile format data can be used in a GIS to place areas of thermokarst ponds onto digital maps for referencing.