The AnnAGNPS model was used to estimate runoff, peak discharge and sediment yield at the event scale in the Carapelle watershed, a Mediterranean medium-size watershed (506 km2) located in Apulia, Southern Italy. The model was calibrated and validated using five years of runoff and sediment yield data measured at a monitoring station located at Ordona – Ponte dei Sauri Bridge. A total of 36 events was used to estimate the output of the model during the period 2007-2011, in comparison to the corresponding observations at the watershed outlet. The model performed well in predicting runoff, as was testified by the high values of the coefficients of efficiency and determination during the validation process. The peak flows predictions were satisfactory especially for the high flow events; the prediction capability of sediment yield was good, even if a slight over-estimation was observed. Finally, the model was used to evaluate the effectiveness of different Management practices (MPs) on the watershed (converting wheat to forest, using vegetated streams, crop rotation corn/soybean, no tillage). While the maximum reduction in sediment yield was achieved converting wheat to forest, the best compromises between soil conservation and agriculture resulted to be crop rotations.