An odontopleurid trilobite remain is described for the fi rst time from Hirnantian (uppermost Ordovician) rocks of Western Gondwana. Very rare material, represented by a single left librigena, comes from a new fossil locality of the Don Braulio Formation in the Eastern Argentine Precordillera. Based on an updated systematic discussion, the fossil is tentatively referred to Eoleonaspis Sheng. Environmental and paleogeographical settings of this fi nding suggest that the genus would be eurytopic, having a cosmopolitan geographical distribution during the Ordovician-Silurian interval. In addition, the new evidence reinforces that scarce odontopleurids, often represented by Eoleonaspis, characterize a trilobite association together with Mucronaspis Destombes, strengthening it as a worldwide Hirnantian biostratigraphic indicator.