MENA region stands at a critical point in its journey of development. The region is characterized by one of the largest and energetic youth population. MENA region needs to address the employment needs of this young population in order become stable, knowledge-based economic region. Female constitute a very significant proportion of total youth population with a very low presentation in the work force. Women entrepreneurship is considered vital to address this disparity. Increased women entrepreneurial activities will not only spur job growth for female but also beneficial for society as a whole. This article explores the entrepreneurial ecosystem of MENA region. The article discusses women entrepreneurship, various challenges and provides specific recommendations to boost female entrepreneurial activities in MENA region.