Online social networks (SNs) are dynamic Web 2.0 applications that can be used for teaching, learning, and research activities. These SNs offer a myriad of collaborative features for generating content and fostering interactive communication. Although many K-16 administrators tend to focus on the negative consequences of using such applications, online social networks, if managed effectively as instructional tools, can provide opportunities for educators to help students develop 21st century skills. This discussion provides an overview how online social networks can be used in education and offers guidelines for implementation.