Abstract : This paper will describe the effect of system location and hull form optimization on a destroyer class ship for three missions. The three missions considered are towed array deployment, gun fire, and underway replenishment. They are all typical destroyer missions; yet, the motion requirements are all different. The towed array deployment mission requires low relative motion at the stern; gun fire requires low absolute motion; and underway replenishment has more human factor considerations than the other two. The mission performance will be evaluated by use of criteria sets and percent time operabilities. Optimized hull forms and locations are compared with original configuration to show the potential improvement in performance. This demonstrates that weapon system performance can be improved by a ship design process focused on reducing specific motions.