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Mathematical Biosciences and Engineering
Article . 2011 . Peer-reviewed
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Mathematical Biosciences and Engineering
Article
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Mathematical analysis and numerical simulation of a model of morphogenesis

Authors: José Ignacio Tello; José Ignacio Tello; Ana I. Muñoz;

Mathematical analysis and numerical simulation of a model of morphogenesis

Abstract

We consider a simple mathematical model of distribution of morphogens (signaling molecules responsible for the differentiation of cells and the creation of tissue patterns). The mathematical model is a particular case of the model proposed by Lander, Nie and Wan in 2006 and similar to the model presented in Lander, Nie, Vargas and Wan 2005. The model consists of a system of three equations: a PDE of parabolic type with dynamical boundary conditions modelling the distribution of free morphogens and two ODEs describing the evolution of bound and free receptors. Three biological processes are taken into account: diffusion, degradation and reversible binding. We study the stationary solutions and the evolution problem. Numerical simulations show the behavior of the solution depending on the values of the parameters.

Keywords

steady states, morphogenesis, Cell Differentiation, Models, Biological, reaction diffusion equations, existence of solutions, numerical simulations., QA1-939, Morphogenesis, Computer Simulation, TP248.13-248.65, Mathematics, Biotechnology

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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
gold