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Lanostane- and cycloartane-type triterpenoids from Abies balsamea oleoresin

descriptionPublicationkeyboard_double_arrow_right Article 04 Jul 2013 France, Canada English Publisher:Beilstein InstitutJournal:Beilstein Journal of Organic Chemistry, volume 9, pages 1,333-1,339 (eissn: 1860-5397, Copyright policy )Funded by:NSERC | unidentified
Authors: Lavoie, Serge; Gauthier, Charles; Legault, Jean; Mercier, Sylvain; Mshvildadze, Vakhtang; Pichette, André;

doi: 10.3762/bjoc.9.150

pmid: 23946828

pmc: PMC3740800

Lanostane- and cycloartane-type triterpenoids from Abies balsamea oleoresin

Abstract

Phytochemical analysis of A. balsamea oleoresin led to the isolation of three new 3,4-seco-lanostane triterpenoids 1–3, one new cycloartane triterpenoid 4 along with fourteen known terpenoids. Structure determinations were based on extensive 1D/2D NMR, IR and MS spectroscopic analyses, and comparison with literature data. The isolated compounds were evaluated in vitro for their cytotoxicity against human cell lines (A549, DLD-1, WS1) and their antibacterial activity against E. coli and S. aureus. Abiesonic acid (6) exhibited weak cytotoxic activity against A549 (IC50 = 22 µM) while compounds 1 and 4 were weakly active against S. aureus (MIC = 25 µM).

Countries
France, Canada
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Keywords

Science, oleoresin, Q, [CHIM.CATA] Chemical Sciences/Catalysis, Organic chemistry, Abies balsamea, Pharmacologie, triterpenoids, [CHIM.ORGA] Chemical Sciences/Organic chemistry, Full Research Paper, QD241-441, [CHIM.OTHE] Chemical Sciences/Other, cycloartane, Chimie, lanostane

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    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 19
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 10%
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
19
Top 10%
Top 10%
Top 10%
Green
Published in a Diamond OA journal