This study examined the hypothesis that the type of list context in which a given item is embedded may affect the way in which it is perceptually processed. In the first experiment, subjects matched four types of test items inserted in four types of lists. The types of test items and the types of lists in which they were embedded were two-letter words, two-letter spelling clusters, unrelated letter pairs, and pairs of novel letters. The first experiment indicated that only unrelated letter pairs were significantly affected by type of list in which they were inserted. The pattern of the effect was confirmed in the latency data of the second experiment and the interpretation was that only unrelated letter and related letter-group contexts were operating in the first two experiments. The third and fourth experiments were concerned with contrasting contexts at the feature and letter levels of processing. By using lists in which type of catch trial either emphasized local features or global aspects of a pattern, the processing times of both familiar and unfamiliar letters were affected. The results of these experiments suggest that information processing models should incorporate structures which represent the way that context selectively facilitates processing of items at particular levels.