The lower third of the face, especially the lips, offer a pivotal contribution to the overall facial appearance. Hyaluronic acid fillers are widely used for lower face support and beautification.This study presents a novel perioral rejuvenation technique. Methods: 70 females were enrolled in the study. The injection technique utilized cannula with bilateral single-entry points. Two different evaluation systems were used.In the upper white lip area, the distances exhibited significant shortening difference before and after treatment in both age groups (P<0.001 for all measurements). Improvement was generally higher among patients injected more than one session. In the lower white lip and chin, the agreement level by physician and patients was fair (P<0.001) while by observers and patients was moderate (P<0.001).The lip flip technique is a novel, safe and effective additive for perioral rejuvenation. J Drugs Dermatol. 2022;21(1):71-76. doi:10.36849/JDD.6344R1.