Drug-drug interactions, dietary interactions, and other factors may cause a drug’s effect on a person to differ from what is anticipated. Beverages and dietary supplements that person consumes (drug-nutrient/food Interaction) or a different illness the person is suffering from (drug-disease interaction). A when a substance impacts a drug’s activity, it is said to be a drug interaction. i.e., the effects change or produce a new impact that neither generates on its own. These interactions could happen by cchanceabuse or a lack of understanding of the relevant substances’ active components. Physicians and pharmacists are aware that various meals and medications can interact when consumed together in terms of food-drug interactions might affect the body’s capacity to utilize a specific diet or medication, or can result in significant adverse consequences. Interactions between clinically significant drugs that could be harmful alterations in pharmacokinetic, pharmacological, or other factors may affect the patient.or their Pharmacodynamic qualities. Some people might be exploited to the adverse drug events are sometimes caused by drug interactions, however this is less common. As a result, it is recommended that patients adhere to their doctor’s and physician’s orders. To achieve the most advantages with the fewest food-drug interactions. The literature survey was carried out by obtaining information from various reviews. And innovative works on general or particular medication and food interactions. This review provides details on the various ways that meals interact with one another.Indrug-drug provide patients with the greatest possible benefit, doctors and pharmacists must carefully choose which medications to prescribe. KEYWORDS: Absorption, adverse drug reaction, distribution, drug-drug metabolism, interactions, and excretion.