Many exoplanets have been detected by the radial velocity method, according to which the motion of a binary system around its center of mass can produce a periodical variation of the Doppler effect of the light emitted by the host star. These variations are influenced by both Newtonian and non-Newtonian perturbations to the dominant inverse-square acceleration; accordingly, exoplanetary systems lend themselves to testing theories of gravity alternative to general relativity. In this paper, we consider the impact of the Standard Model Extension (a model that can be used to test all possible Lorentz violations) on the perturbation of radial velocity and suggest that suitable exoplanets’ configurations and improvements in detection techniques may contribute to obtaining new constraints on the model parameters.