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Cucurbitacins from the Leaves of Citrullus colocynthis (L.) Schrad

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 30 Sep 2015 France English Publisher:MDPI AGJournal:Molecules, volume 20, pages 18,001-18,015 (eissn: 1420-3049, Copyright policy )
Authors: Chawech, Rachid; Jarraya, Raoudha; Girardi, Cynthia; Vansteelandt, Marieke; Marti, Guillaume; Nasri, Imen; Racaud-Sultan, Claire; +1 Authors

doi: 10.3390/molecules201018001

pmid: 26437392

pmc: PMC6332406

Cucurbitacins from the Leaves of Citrullus colocynthis (L.) Schrad

Abstract

Two new tetracyclic cucurbitane-type triterpene glycosides were isolated from an ethyl acetate extract of Citrullus colocynthis leaves together with four known cucurbitacins. Their structures were established on the basis of their spectroscopic data (mainly NMR and mass spectrometry). Evaluation of the in vitro cytotoxic activity of the isolated compounds against two human colon cancer cell lines (HT29 and Caco-2) and one normal rat intestine epithelial cell line (IEC6), revealed that one of the isolated compounds presented interesting specific cytotoxic activity towards colorectal cell lines.

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Keywords

cytotoxicity., Dose-Response Relationship, Drug, Molecular Structure, <i>Citrullus colocynthis</i>, Plant Extracts, 610, Organic chemistry, Cucurbitacins, cucurbitacins, 540, Antineoplastic Agents, Phytogenic, Article, [SDV] Life Sciences [q-bio], Plant Leaves, Inhibitory Concentration 50, QD241-441, Cell Line, Tumor, cytotoxicity, Humans, Citrullus colocynthis, Nuclear Magnetic Resonance, Biomolecular

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    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
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    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
37
Top 10%
Top 10%
Top 10%
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gold
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