New Cembranoid Diterpenes from the Cultured Octocoral Nephthea columnaris
Copyright policy )New Cembranoid Diterpenes from the Cultured Octocoral Nephthea columnaris
Two new 15-hydroxycembranoid diterpenes, 2β-hydroxy-7β,8α-epoxynephthenol (1) and 2β-hydroxy-11α,12β-epoxynephthenol (2), were isolated from extracts of the octocoral Nephthea columnaris along with a new natural cembrane, epoxynephthenol (3) and a known sterol, nephalsterol A (4). The structures of cembranes 1–3 were elucidated by spectroscopic methods and comparison of the spectroscopic data with those of related analogues. The cytotoxicity of metabolites 1–4 against a panel of tumor cells is also described.
Molecular Structure, Cytotoxins, Nephthea columnaris, Organic chemistry, U937 Cells, Anthozoa, octocoral, Article, QD241-441, cembrane, Neoplasms, MCF-7 Cells, <i>Nephthea columnaris</i>, cytotoxicity, Animals, Humans, Diterpenes, nephalsterol
Molecular Structure, Cytotoxins, Nephthea columnaris, Organic chemistry, U937 Cells, Anthozoa, octocoral, Article, QD241-441, cembrane, Neoplasms, MCF-7 Cells, <i>Nephthea columnaris</i>, cytotoxicity, Animals, Humans, Diterpenes, nephalsterol
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