Synthesis and in Vitro Antimicrobial Evaluation of New N-Heterocyclic Diquaternary Pyridinium Compounds
Copyright policy )Synthesis and in Vitro Antimicrobial Evaluation of New N-Heterocyclic Diquaternary Pyridinium Compounds
A series of bis-pyridinium quaternary ammonium salts (bis-PyQAs) with different aryl and heteroaryl moieties were synthesized and their antimicrobial activity investigated. The inhibition effect of the compounds was evaluated against bacteria, molds and yeasts; the activities were expressed as the minimum inhibitory concentrations (MIC). The relationships between the structure descriptors (logP, polarizability, polar surface area (2D), van der Waals area (3D)) and the biological activity of the tested bis-PyQAs are discussed.
antimicrobial activity, Bacteria, pyridinium quaternary salts; antimicrobial activity; 4-[2-(pyridin-4-yl)ethyl]pyridine, 4,4'-bipyridine, Fungi, 4-[2-(pyridin-4-yl)ethyl]pyridine, 4,4'-bipyridine, Organic chemistry, Pyridinium Compounds, Chemistry Techniques, Synthetic, Microbial Sensitivity Tests, pyridinium quaternary salts, Article, QD241-441, Anti-Infective Agents, Hydrophobic and Hydrophilic Interactions
antimicrobial activity, Bacteria, pyridinium quaternary salts; antimicrobial activity; 4-[2-(pyridin-4-yl)ethyl]pyridine, 4,4'-bipyridine, Fungi, 4-[2-(pyridin-4-yl)ethyl]pyridine, 4,4'-bipyridine, Organic chemistry, Pyridinium Compounds, Chemistry Techniques, Synthetic, Microbial Sensitivity Tests, pyridinium quaternary salts, Article, QD241-441, Anti-Infective Agents, Hydrophobic and Hydrophilic Interactions
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).14 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!