Chemical Genetics of Acetyl-CoA Carboxylases
Copyright policy )Chemical Genetics of Acetyl-CoA Carboxylases
Chemical genetic studies on acetyl-CoA carboxylases (ACCs), rate-limiting enzymes in long chain fatty acid biosynthesis, have greatly advanced the understanding of their biochemistry and molecular biology and promoted the use of ACCs as targets for herbicides in agriculture and for development of drugs for diabetes, obesity and cancers. In mammals, ACCs have both biotin carboxylase (BC) and carboxyltransferase (CT) activity, catalyzing carboxylation of acetyl-CoA to malonyl-CoA. Several classes of small chemicals modulate ACC activity, including cellular metabolites, natural compounds, and chemically synthesized products. This article reviews chemical genetic studies of ACCs and the use of ACCs for targeted therapy of cancers.
- Chenzhou First People's Hospital China (People's Republic of)
- Southern Illinois University School of Medicine United States
- Department of Microbiology United States
- The First People's Hospital of Changzhou China (People's Republic of)
- University of South China China (People's Republic of)
fatty acid biosynthesis, ACC chemical genetics, Organic chemistry, Review, acetyl-CoA carboxylase, QD241-441, Neoplasms, cancer therapy, Animals, Humans, ACC inhibitors, Enzyme Inhibitors, Protein Processing, Post-Translational, Acetyl-CoA Carboxylase
fatty acid biosynthesis, ACC chemical genetics, Organic chemistry, Review, acetyl-CoA carboxylase, QD241-441, Neoplasms, cancer therapy, Animals, Humans, ACC inhibitors, Enzyme Inhibitors, Protein Processing, Post-Translational, Acetyl-CoA Carboxylase
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