Uranium, a cornerstone for nuclear energy, facilitates a clean and efficient energy conversion. In the era of global clean energy initiatives, uranium resources have emerged as a vital component for achieving sustainability and clean power. To fulfill the escalating demand for clean energy, continual advancements in uranium mining technologies are imperative. Currently, established uranium mining methods encompass open-pit mining, underground mining, and in situ leaching (ISL). Notably, in situ leaching stands out due to its environmental friendliness, efficient extraction, and cost-effectiveness. Moreover, it unlocks the potential of extracting uranium from previously challenging low-grade sandstone-hosted deposits, presenting novel opportunities for uranium mining. This comprehensive review systematically classifies and analyzes various in situ leaching techniques, exploring their core principles, suitability, technological advancements, and practical implementations. Building on this foundation, it identifies the challenges faced by in situ leaching and proposes future improvement strategies. This study offers valuable insights into the sustainable advancement of in situ leaching technologies in uranium mining, propelling scientific research and practical applications in the field.