The purpose of this paper is to introduce the concept of graded 2-prime ideals as a new generalization of graded prime ideals. We show that graded 2-prime ideals and graded semi-prime ideals are different. Furthermore, we show that graded 2-prime ideals and graded weakly prime ideals are also different. Several properties of graded 2-prime ideals are investigated. We study graded rings in which every graded 2-prime ideal is graded prime, we call such a graded ring a graded 2-P-ring. Moreover, we introduce the concept of graded semi-primary ideals, and show that graded 2-prime ideals and graded semi-primary ideals are different concepts. In fact, we show that graded semi-primary, graded 2-prime and graded primary ideals are equivalent over Z-graded principal ideal domain.