This paper aims to establish a new hybrid class of special polynomials, namely, the Fubini–Bell-based Appell polynomials. The monomiality principle is used to derive the generating function for these polynomials. Several related identities and properties, including symmetry identities, are explored. The determinant representation of the Fubini–Bell-based Appell polynomials is also established. Furthermore, some special members of the Fubini–Bell-based Appell family—such as the Fubini–Bell-based Bernoulli polynomials and the Fubini–Bell-based Euler polynomials—are derived, with analogous results presented for each. Finally, computational results and graphical representations of the zero distributions of these members are investigated.