The present paper investigates the following inhomogeneous generalized Hartree equation iu˙+Δu=±|u|p−2|x|b(Iα∗|u|p|·|b)u, where the wave function is u:=u(t,x):R×RN→C, with N≥2. In addition, the exponent b>0 gives an unbounded inhomogeneous term |x|b and Iα≈|·|−(N−α) denotes the Riesz-potential for certain 0<α<N. In this work, our aim is to establish the local existence of solutions in some radial Sobolev spaces, as well as the global existence for small data and the decay of energy sub-critical defocusing global solutions. Our results complement the recent work (Sharp threshold of global well-posedness versus finite time blow-up for a class of inhomogeneous Choquard equations, J. Math. Phys. 60 (2019), 081514). The main challenge in this work is to overcome the singularity of the unbounded inhomogeneous term |x|b for certain b>0.