The curvature characteristics of particular classes of Finsler spaces, such as homogeneous Finsler spaces, are one of the major issues in Finsler geometry. In this paper, we have obtained the expression for S-curvature in homogeneous Finsler space with a generalized Matsumoto metric and demonstrated that the homogeneous generalized Matsumoto space with isotropic S-curvature has to vanish the S-curvature. We have also derived the expression for the mean Berwald curvature by using the formula of S-curvature.